Japanese – Communicable Diseases Research

A replication-competent smallpox vaccine LC16m8Δ-based COVID-19 vaccine

Article

Published on 2022-12-012022-11-15
Journal: Emerging Microbes & Infections
[Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] acute respiratory syndrome analysed antibody antibody titres BALB/c BALB/c mouse boost CD4 CD8 cellular cellular immunity coronavirus coronavirus disease COVID-19 COVID-19 vaccine Delta/B.1.617.2 variant of concern effective eight elicited emerging and re-Emerging coronaviruses glycoprotein homologous humoral Humoral immunity immunization Japanese LC16m8 less mice motif multifunctional neutralized Neutralizing activity patients with COVID-19 polybasic prime-boost immunization. provide recombinant replication-competent viral S-specific antibody S1/S2 cleavage site SARS-CoV-2 serum sample significantly lower Strains T-cell immune responses T-cell immunity T-cell Response the S protein Vaccine Vaccine development vaccine platform variant vector viral vectors virus Wuhan
[DOI] 10.1080/22221751.2022.2122580 PMC 바로가기

Immunological responses following the third dose of the BNT162b2 SARS-CoV-2 vaccine among Japanese healthcare workers

Article

Published on 2022-11-012022-11-15
Journal: Journal of infection and chemotherapy : official j
[Category] COVID19(2023년), SARS, 진단,

Development of IgA vasculitis with severe glomerulonephritis after COVID-19 vaccination: a case report and literature review

Article

Published on 2022-11-012022-11-15
Journal: CEN case reports
[Category] 진단,

New-onset dermatomyositis following COVID-19: A case report

Article

Published on 2022-10-242022-11-16
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 치료기술,

[키워드] acute respiratory syndrome addition anti-aminoacyl tRNA synthetase (ARS) antibodies anti-synthetase antibodies antibodies antibody association autoantibody Autoimmune Autoimmune disease Autoimmune diseases biochemical analysis Biological Case report caused Chest clinical feature Clinical features complications Computed tomography contributed coronavirus Coronavirus disease 2019 Corticosteroids cough COVID-19 de novo dermatomyositis dermatomyositis. develop diagnosed diagnostic Dyspnea edema elevations enzyme-linked immunosorbent exacerbate Fever highlight Hospitalization IgG ILD immunoblot infected individual Infectious disease Inflammatory interstitial Interstitial lung disease Japan Japanese lower lobe Lungs male manifestation MOST myalgia myopathies myositis Occurrence organ pathological findings Patient polymerase chain positive Prednisolone presenting profile respiratory symptom SARS-CoV-2 skin rash sore throat Swab syndrome tested transaminases treated tRNA weakness
[DOI] 10.3389/fimmu.2022.1002329 PMC 바로가기

Humoral immune response against BNT162b2 mRNA COVID-19 vaccine in patients with rheumatic disease undergoing immunosuppressive therapy: A Japanese monocentric study

Article

Published on 2022-10-212022-11-15
Journal: Medicine
[Category] COVID19(2023년), SARS, 진단,

[키워드] acute respiratory syndrome addition Analysis analyzed Antibody titer attenuate Baricitinib BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 vaccine Combination controls coronavirus coronavirus disease COVID-19 COVID-19 vaccine disease domain dose Glucocorticoids healthy volunteer humoral immune response immunomodulatory Immunosuppressant immunosuppressants immunosuppressive immunosuppressive agent Immunosuppressive medication impair inhibitor inhibitors interleukin-17 interleukin-6 investigated Japanese Kagawa methotrexate much lower Necrosis of BNT162b2 Outpatient Patient patients treated reduced rheumatic disease SARS-CoV-2 SARS-CoV-2 spike protein second dose serum serum antibody significantly significantly lower Spike protein the patient therapeutic agent Treatment university Vaccine
[DOI] 10.1097/MD.0000000000031288 PMC 바로가기

A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-Like Protease Inhibitor, in Japanese Patients with Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a Part

Article

Published on 2022-10-182022-11-15
Journal: Antimicrobial Agents and Chemotherapy
[Category] COVID19(2023년), SARS, 치료제,

[키워드] acute respiratory syndrome All adverse event Asymptomatic baseline clinical coronavirus coronavirus disease COVID-19 Culture demonstrated double-blind Efficacy and safety ensitrelvir fumaric acid greater group groups intention-to-treat population Japan Japanese log median time Mild Mild-to-moderate moderate multicenter novel oral Part Patient phase phase 2/3 Placebo positive Primary outcome proof-of-concept study protease Protease inhibitor Randomized receive reduced registry Result S-217622 SARS-CoV-2 SARS-CoV-2 3C-like protease inhibitor SARS-CoV-2 clearance SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral the SARS-CoV-2 tissue Treatment viral clearance Viral RNA viral titer viral titer.
[DOI] 10.1128/aac.00697-22 PMC 바로가기

Safety, Tolerability, and Pharmacokinetics of the Novel Antiviral Agent Ensitrelvir Fumaric Acid, a SARS-CoV-2 3CL Protease Inhibitor, in Healthy Adults

Article

Published on 2022-10-182022-11-15
Journal: Antimicrobial Agents and Chemotherapy
[Category] COVID19(2023년), SARS, 치료제,

Poor vaccine responsiveness towards third-dose mRNA vaccine of COVID-19 in Japanese older people

Article

Published on 2022-10-012022-11-15
Journal: The Journal of Infection
[Category] Fulltext, MERS, 진단,

[키워드] Abstract acute respiratory syndrome antibody coronavirus Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Japanese mRNA vaccine Older Poor severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Vaccine vaccine booster Vaccine failure Vaccine failure.
[DOI] 10.1016/j.jinf.2022.07.007 PMC 바로가기

The way forward for neuroethics in Japan: A review of five topics surrounding present challenges

Review article

Published on 2022-10-012022-10-05
Journal: Neuroscience Research
[Category] 비임상,

[키워드] Brain comparison Contact FIVE Human identity Impact intervene introduced Japan Japanese methodology Neuroethics non-human primates Perspective Psychiatric public health Research rule Support
[DOI] 10.1016/j.neures.2022.07.006 [Article Type] Review article

Changes in diagnostic usefulness of the JRS scoring system in COVID-19 pneumonia by SARS-CoV-2 vaccination

SARS-CoV-2 백신접종에 따른 COVID-19 폐렴에서 JRS 점수 체계의 진단 유용성 변화

Article

Published on 2022-10-012022-09-11
Journal: Journal of infection and chemotherapy : official j
[Category] COVID19(2023년), SARS, 변종, 진단, 치료기술,